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Additionally, if the drug material is biologically created, the incomplete removal in the microorganism through purification can result in the drug compound acquiring high endotoxin levels.
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This established value means that if a parenteral drug maker is using the LAL technique for endotoxin screening of Cyanocobalamin Inj., the product or service may have not more than 350 EU/ml of product or service.
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With respect to producing products and transfer lines, depyrogenation by dilution has ordinarily been the method of option. Utilization of strong alkali or oxidizing Option has from time to time been employed to scale back pyrogens in these storage/delivery units.
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